Rembrandt: Man in Armour. |
Researchers have restored vision in old mice and in mice with damaged retinal nerves by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, published on 2 December in Nature1, suggests a new approach to reversing age-related decline, by reprogramming some cells to a younger state in which they are better able to repair or replace damaged tissue.
Black mice in a container on a lab bench.
Mice with retinal-nerve damage can have their vision restored through cell reprogramming.
researchers also caution that the work has so far has been carried out only in mice, and it remains to be seen whether the approach will translate to people, or to other tissues and organs that are ravaged by time.
it will be an epigenetics gold rush - new controls for gene expression
- if reversal of biological clock restores vision in old mice
reprogramming’ approach seems to make old cells young again.
David Sinclair, a geneticist at Harvard Medical School in Boston, Massachusetts, asks:
Can you reverse the clock?So,
These results clearly show that tissue regeneration in mammals can be enhanced,says an other, Juan Carlos Izpisua Belmonte, here.
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